China Pitavastatin Calcium produsen lan supplier |CPF

Pitavastatin Kalsium

Katrangan singkat:

Jeneng API	Indikasi	Spesifikasi	DMF AS	EU DMF	CEP
Pitavastatin Kalsium	Hiperkolesterolemia	Ing-Omah

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Detail Produk

Tag produk

DETAIL PRODUK

匹伐他汀钙	Pitavastatin	147526-32-7	Ing-Omah
PI-5		3800-06-4	Ing-Omah
PI-6		145516-11-4	Ing-Omah
PI-7		121660-11-5	Ing-Omah

Katrangan

Pitavastatin Calcium (NK-104 hemicalcium) minangka inhibitor reduktase hydroxymethylglutaryl-CoA (HMG-CoA) sing kuat.Pitavastatin Calcium (NK-104 hemicalcium) nyegah sintesis kolesterol saka asam asetat kanthi IC50 5,8 nM ing sel HepG2.Pitavastatin Calcium minangka inducer reseptor lipoprotein-kolesterol (LDL-C) hepatosit sing efisien.Aktivitas anti-kanker.

Latar mburi

Pitavastatin Calcium minangka inhibitor kompetitif enzim HMGCR (HMG-CoA reductase) nyebabake nyuda sintesis kolesterol LDL.Panaliten alternatif nuduhake yen pitavastatin bisa nyuda produksi oksigen ing sel endothelial kanthi nyegah NADPH oksidase.Kajaba iku, pitavastatin nyuda ekspresi mRNA eNOS nalika nambah respon gumantung NO sing dirangsang dening acetylcholine lan calcium ionophore, A23187.Salajengipun, pitavastatin nyegah regulasi saluran kalium sing diaktifake kalsium konduktansi kanthi nyuda tingkat kolesterol ing sel.

Lumbung

4°C, nglindhungi saka cahya

* Ing solvent: -80°C, 6 sasi;-20°C, 1 wulan (lindhungi saka cahya)

Struktur kimia

Pitavastatin Calcium