Daclatasvir Dihydrochloride
Katrangan
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) minangka obat kuat lan aktif sacara lisan.Protein HCV NS5Ainhibitor karoEC50s sawetara 9-146 pM kanggomacem-macem genotipe replika HCV.Daclatasvir dihydrochloride uga apolipeptida pengangkut anion organik 1B (OATP1B)lanOATP1B3inhibitor karoIC50s saka 1,5 µM lan 3,27 µM, mungguh.
IC50& Target
EC50: 50 pM (genotipe replika HCV 1a), 9 pM (genotipe replika HCV 1b), 71 pM (genotipe replika HCV 2a), 146 pM (genotipe replika HCV 3a), 12 pM (genotipe replika HCV 33 pM) lan HCV replika genotipe 5a)[1]
Kd: 8 nM (NS5A33-202) lan 210 nM (NS5A26-202)[2]
IC50: 1,5 µM (OATP1B) lan 3,27 µM (OATP1B3)[3]
Ing Vitro
Daclatasvir (BMS-790052) nduduhake aktivitas hambat sing kuat marang kabeh genotipe sing diuji, kanthi EC50nilai kiro-kiro saka 9 pm kanggo 146 pm.Daclatasvir nyegah genotipe replika HCV 1a, 1b, 2a, 3a, 4a lan 5a kanthi EC50angka 50 pm, 9 pm, 71 pm, 146 pm, 12 pm lan 33 pm, mungguh.Daclatasvir minangka inhibitor kuat saka virus infèksi genotipe 2a JFH-1 sing replikasi ing kultur sel (EC50= 28 pm)[1].Daclatasvir (BMS-790052) ikatan erat karo NS5A33-202 lan NS5A26-202 karo Kds saka 8 nM lan 210 nM, mungguh[2].
Lumbung
| bubuk | -20°C | 3 taun |
| 4°C | 2 taun | |
| Ing solvent | -80°C | 6 wulan |
| -20°C | 1 wulan |
Uji klinis
| Nomer NCT | Sponsor | kahanan | Tanggal wiwitan | Urutane |
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| NCT03485846 | R-Pharm|Almedis | Hepatitis C kronis Genotipe 1b | 27 November 2017 | Fase 2 |
| NCT01016912 | Bristol-Myers Squibb | Infeksi Hepatitis C | Desember 2009 | Fase 2 |
| NCT01629732 | Bristol-Myers Squibb | Virus Hepatitis C | Maret 2013 | Fase 2 |
| NCT01497834 | Bristol-Myers Squibb | Hepatitis C | Januari 2012 | Fase 3 |
| NCT01973049 | Bristol-Myers Squibb | Hepatitis C | Desember 2013 | Fase 3 |
| NCT00663208 | Bristol-Myers Squibb | Hepatitis C kronis | Mei 2008 | Fase 2 |
| NCT02576314 | Pusat Riset Kemanusiaan lan Kesehatan|Beijing 302 Hospital | Infeksi Hepatitis C kronis | Mei 2015 | Fase 3 |
| NCT02756936 | Pusat Riset Asli, Mesir|Zeta Pharma Pharmaceutical Industries | Sehat | Februari 2016 | Fase 1 |
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| NCT03706898 | Viriom | HIV-1-infèksi|Gagal ati | 1 Oktober 2018 | Fase 1 |
| NCT02319031 | Bristol-Myers Squibb | Hepatitis C | Februari 2015 | Fase 3 |
| NCT02124044 | Pusat Klinis Institut Kesehatan Nasional (CC)|Institut Alergi lan Penyakit Infèksi Nasional (NIAID)|Bristol-Myers Squibb | HIV-HCV | Februari 2014 | Fase 2 |
| NCT02551861 | Bristol-Myers Squibb | Hepatitis C | Desember 2015 | Fase 2 |
| NCT00859053 | Bristol-Myers Squibb | Insufisiensi Hepatik | Maret 2009 | Fase 1 |
| NCT01257204 | Bristol-Myers Squibb | Virus Hepatitis C | Desember 2010 | Fase 2 |
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| NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatitis C, kronis | 29 Maret 2019 | Fase 2 | Fase 3 |
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| NCT03169348 | Universitas Assiut | Hepatitis C | 1 November 2017 | Ora Ditrapake |
| NCT02323594 | Bristol-Myers Squibb | Infeksi Hepatitis C | Desember 2014 | Fase 1 |
| NCT03537196 | Institut Nasional Prancis kanggo Riset Kesehatan lan Medis-Badan Nasional Prancis kanggo Riset AIDS lan Hepatitis Viral (Inserm-ANRS) | Hepatitis C|Penggunaan Narkoba|Hepatitis C Virus | 13 November 2018 | Fase 4 |
| NCT02103569 | Bristol-Myers Squibb | Hepatitis C | April 2014 | Fase 1 |
| NCT02772744 | Universitas Zagazig|Universitas Kairo | Hepatitis C | 1 November 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Hepatitis C | Januari 2013 | Fase 3 |
| NCT02496078 | Bristol-Myers Squibb | Hepatitis C | Agustus 2015 | Fase 3 |
| NCT01425970 | Bristol-Myers Squibb | Hepatitis C | Mei 2012 | Fase 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatitis C, Genotipe 1 | Desember 2011 | Fase 3 |
| NCT01573351 | Bristol-Myers Squibb | Virus Hepatitis C | Mei 2012 | Fase 3 |
| NCT01938625 | Janssen R&D Irlandia | Hepatitis C, kronis | 12 Desember 2013 | Fase 2 |
| NCT01492426 | Bristol-Myers Squibb | Hepatitis C | Januari 2012 | Fase 3 |
| NCT03480932 | Sekolah Kesehatan Masyarakat Johns Hopkins Bloomberg|Institut Nasional Penyalahgunaan Narkoba (NIDA)|Pusat Riset lan Pendidikan AIDS YR Gaitonde | Hepatitis C, kronis | 2 Februari 2018 | Fase 2 | Fase 3 |
| NCT03163849 | Universitas Assiut | Hepatitis kronis c | 1 September 2019 | Fase 3 |
| NCT01581203 | Bristol-Myers Squibb | Virus Hepatitis C | Mei 2012 | Fase 3 |
| NCT01492504 | Bristol-Myers Squibb | Hepatitis C | 7 Februari 2012 |
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| NCT03686722 | Mohamed Raslan|Universitas Ain Shams|Pusat Riset Narkoba, Kairo, Mesir | Diabetes Mellitus, Tipe 2|Hepatitis C|Interaksi Obat | 9 September 2017 | Fase 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatitis C, kronis | 30 September 2014 | Fase 2 |
| NCT02349048 | Janssen Research & Development, LLC | Virus Hepatitis C | Januari 2015 | Fase 2 |
| NCT03882307 | Universitas Assiut | Hepatitis C, kronis | Mei 2020 | Fase Awal 1 |
| NCT02758509 | Parc de Salut Mar | Hepatitis C kronis | Sirosis | 1 Januari 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Hepatitis C | Maret 2013 | Fase 2 |
| NCT03549832 | Universitas Assiut|Universitas Sohag|Universitas Lembah Kidul | Koinfeksi HCV | 1 Januari 2018 | Ora Ditrapake |
| NCT02161939 | Bristol-Myers Squibb | Hepatitis C kronis |
| |
| NCT01309932 | Bristol-Myers Squibb | Hepatitis C | Maret 2011 | Fase 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatitis C | 28 Februari 2014 | Fase 3 |
| NCT02640157 | AbbVie | Hepatitis C kronis|Hepatitis C Virus|Genotype 3 Hepatitis C Virus | Desember 2015 | Fase 3 |
| NCT02032875 | Bristol-Myers Squibb | Hepatitis C | Maret 2014 | Fase 3 |
| NCT02624063 | Universitas Federal São Paulo | Hepatitis C, kronis | Desember 2015 | Fase 4 |
| NCT00546715 | Bristol-Myers Squibb | Hepatitis C kronis | November 2007 | Fase 1 | Fase 2 |
| NCT01718145 | Bristol-Myers Squibb | Infeksi Virus Hepatitis C | November 2012 | Fase 3 |
| NCT01616524 | Bristol-Myers Squibb | Virus Hepatitis C (HCV) | Juli 2012 | Fase 3 |
| NCT02032901 | Bristol-Myers Squibb | Hepatitis C | Januari 2014 | Fase 3 |
| NCT03540212 | Universitas Ain Shams | Infeksi HCV kronis | 10 Desember 2017 | Fase 2 | Fase 3 |
| NCT02097966 | Bristol-Myers Squibb | Hepatitis C kronis |
| |
| NCT02596880 | Universitas Ilmu Kedokteran Tehran | Hepatitis C|Sirosis | September 2015 | Fase 3 |
| NCT04019717 | Atea Pharmaceuticals, Inc. | Hepatitis C|Hepatitis C, Kronis|Hepatitis C kronis|Infeksi Virus Hepatitis C|Infeksi HCV | 20 Juni 2019 | Fase 2 |
| NCT02992457 | Universitas Tanta | Hepatitis C | Januari 2015 | Fase 4 |
| NCT03547895 | Universitas Zagazig | Sirosis dekompensasi | 1 Juni 2015 | Ora Ditrapake |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Hepatitis C | November 2016 | Fase 3 |
| NCT01051414 | Bristol-Myers Squibb | Infeksi Hepatitis C | April 2010 | Fase 2 |
| NCT02309450 | Institut Nasional Prancis kanggo Riset Kesehatan lan Medis-Badan Nasional Prancis kanggo Riset AIDS lan Hepatitis Viral (Inserm-ANRS)|Bristol-Myers Squibb | Infeksi Virus Hepatitis C Genotipe 4 | Desember 2014 | Fase 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Virus Hepatitis C | Juli 2012 | Fase 2 |
| NCT03186313 | Rumah Sakit Hati Mesir|Rumah Sakit Wadi El Nil | Hepatitis C | September 2016 | Fase 3 |
| NCT03063723 | Rumah Sakit Afiliasi Katelu, Universitas Sun Yat-Sen | Hepatitis C kronis (Gangguan) | 1 Januari 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Hepatitis C kronis | Oktober 2009 | Fase 1 |
| NCT01725542 | Institut Nasional Prancis kanggo Riset Kesehatan lan Medis-Badan Nasional Prancis kanggo Riset AIDS lan Hepatitis Viral (Inserm-ANRS)|Bristol-Myers Squibb | Infeksi HCV-HIV | Desember 2012 | Fase 2 |
| NCT02282709 | Yayasan kanggo Riset Ati | Hepatitis C kronis | Februari 2014 | Fase 3 |
| NCT02032888 | Bristol-Myers Squibb | Hepatitis C | Februari 2014 | Fase 3 |
| NCT03247296 | Universitas MTI | Hepatitis C | 28 Februari 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Hepatitis C | September 2011 | Fase 3 |
| NCT02556086 | Bristol-Myers Squibb | Hepatitis C | Desember 2015 | Fase 2 |
| NCT01741545 | Bristol-Myers Squibb | Virus Hepatitis C | 31 Maret 2013 | Fase 3 |
| NCT01866930 | Bristol-Myers Squibb | Infeksi Hepatitis C kronis | 11 Juli 2013 | Fase 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatitis C, kronis | Januari 2015 | Fase 2 |
| NCT01797848 | Bristol-Myers Squibb | Hepatitis C | Juni 2014 | Fase 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Universitas Assiut | Hepatitis C | Juni 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Hepatitis C | Juni 2014 | Fase 1 |
| NCT01125189 | Bristol-Myers Squibb | Virus Hepatitis C | Juli 2010 | Fase 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Interaksi Obat | 19 November 2018 | Fase 1 |
| NCT01012895 | Bristol-Myers Squibb | Hepatitis C kronis | Desember 2009 | Fase 2 |
| NCT02565888 | Universitas Radboud | Hepatitis C|HIV | November 2015 | Fase 1 |
| NCT02555943 | Pusat Riset Kemanusiaan lan Kesehatan|Rumah Sakit 302 Beijing|Rumah Sakit Nanfang Universitas Kedokteran Kidul | Infeksi Hepatitis C kronis|Koinfeksi HBV|Reaktivasi Hepatitis B | Februari 2015 | Fase 2 | Fase 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Pusat Riset California Selatan | Hepatitis C|Sirosis | Januari 2015 | Fase 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Rumah Sakit Universitas Soonchunhyang|Universitas Dankook|Rumah Sakit Universitas Nasional Chungnam|Rumah Sakit Universitas Konyang|Rumah Sakit Universitas Eulji|Rumah Sakit Saint Vincent, Korea|Rumah Sakit Universitas Konkuk|Rumah Sakit St. Mary Cheongju, Cheongju , Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|The Catholic University of Korea | Hepatitis C | Februari 2016 | Fase 4 |
| NCT02104843 | Bristol-Myers Squibb | Hepatitis C | April 2014 | Fase 1 |
| NCT01428063 | Bristol-Myers Squibb | Infeksi Virus Hepatitis C | September 2011 | Fase 2 |
| NCT02123654 | Bristol-Myers Squibb | Infeksi Virus Hepatitis C | April 2014 | Fase 3 |
| NCT02565862 | Universitas Radboud | Hepatitis C|Diabetes Mellitus|Resistensi Insulin | Januari 2016 | Fase 1 |
| NCT04211844 | Universitas Ain Shams | Hepatitis C kronis | 1 Oktober 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Infeksi Hepatitis C | Juni 2009 | Fase 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Gagal Ginjal, Kronis|Hepatitis C | 15 Maret 2019 | Fase 3 |
| NCT01448044 | Bristol-Myers Squibb | Hepatitis C | Desember 2011 | Fase 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Hepatitis C kronis | Juni 2011 | Fase 2 |
| NCT01842451 | Vertex Pharmaceuticals Incorporated | Hepatitis C|CHC|HCV|Hepatitis C kronis | Juni 2013 | Fase 2 |
| NCT02762448 | Rumah Sakit Kota Tainan | Hepatitis c | Juli 2016 |
|
| NCT02473211 | Pusat Riset Kemanusiaan lan Kesehatan|Beijing 302 Hospital | Infeksi Hepatitis C kronis | Januari 2015 | Fase 2 | Fase 3 |
| NCT01455090 | Bristol-Myers Squibb | Hepatitis C kronis | 30 November 2011 | Fase 2 |
| NCT03490097 | Universitas Ain Shams | Hepatitis c|Sindrom Metabolik kronis | 1 Desember 2017 | Fase 2 | Fase 3 |
| NCT01170962 | Bristol-Myers Squibb | Virus Hepatitis C | Agustus 2010 | Fase 2 |
| NCT02333292 | Rumah Sakit Universitas Valme|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias Rumah Sakit Umum Universitario de Alicante|Hospital Universitario Araba|Hospital Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Hospital Universitario Virgen Macarena|Complexo Hospitalario Universitario de Vigo|Universidad de Vigo Navarra|Hospital Clinico Universitario San Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Virgen Regional Universitario|Hospital la Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell | Infeksi Hepatitis C kronis | Desember 2014 |
|
| NCT03200184 | Universitas Ilmu Kedokteran Tehran | Hepatitis C | 1 September 2016 | Fase 4 |
| NCT03188276 | Rumah Sakit Afiliasi Katelu, Universitas Sun Yat-Sen | Hepatitis C kronis | 1 Februari 2016 | Fase Awal 1 |
| NCT01830205 | Bristol-Myers Squibb | Hepatitis C | September 2012 | Fase 1 |
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