Sacubitril Hemicalcium
沙库比曲半钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | Ing-Omah |
沙库比曲钠盐 | 149690-05-1 | Ing-Omah | |
LCZ-4 | 1426129-50-1 | Ing-Omah | |
LCZ-7 | 1012341-48-8 | Ing-Omah | |
LCZ-8 | 1012341-50-2 | Ing-Omah | |
LCZ-9 | 149690-12-0 | Ing-Omah |
Latar mburi
Garam hemicalcium AHU-377 minangka wujud uyah hemicalcium saka AHU-377.Iki minangka inhibitor neprilysin kanthi nilai IC50 5 nM [1].
AHU-377 lan antagonis reseptor angiotensin II AT1 valsartan nyusun LCZ696 kanthi rasio molar 1: 1.LCZ696 minangka inhibitor neprilysin reseptor angiotensin.Bisa nyuda tekanan getih lan bisa dadi obat anyar kanggo perawatan gagal jantung.AHU-377 minangka pro-obat, bisa diowahi kanthi pembelahan enzimatik etil ester dadi bentuk aktif LBQ657.Dilaporake yen AHU-377 (30 lan 100 mg / kg, PO) bisa nyebabake efek antihipertensi kanthi cara gumantung dosis ing tikus DAHI-SS.Nanging ing tikus hipertensi DOCA-uyah, nuduhake pengurangan sing ringkih [2, 3].
Referensi:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.12 Mei 1995;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Peran potensial valsartan + AHU377 (LCZ696) ing perawatan gagal jantung.Pakar Opin Investig Drugs.2013 Agustus;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Khasiat komparatif AHU-377, inhibitor neprilysin sing kuat, ing rong model tikus hipertensi gumantung volume.BMC Pharmacology 2011, 11 (Suppl 1): P33.
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